The hybrid nature of the SAIOs gives them both excellent biocompatibility and imaging performance. This core is then coated with an iron oxide surface to give it paramagnetic properties at room temperature. The SAIO is a special nanoparticle that consist of a polysaccharide core made primarily with dextran cross-linked with other molecules. This allows it to circulate across blood vessels in the body. The particle is 5 nanometers in size, which is about 1,500 times smaller than the microvascular diameter. The researchers developed a nanoparticle-based MRI contrast agent, called SAIO (Supramolecular Amorphous-like Iron Oxide). There have been some attempts to use paramagnetic iron-based nanoparticles as contrasting agents, but their renal clearance profile must be improved to prevent undesirable accumulation in the liver and other organs.Ī collaborative research team led by Professor CHEON Jinwoo, the director of the Center for Nanomedicine (CNM), Institute for Basic Science (IBS) at Yonsei University, Seoul, South Korea and Professor CHOI Byoung Wook from Yonsei University College of Medicine developed a high-performance MRI contrast agent for 3D vascular mapping. However, even then there are some health risks of nephrogenic systemic fibrosis for patients with poor kidney functions. #Mri con contraste free#Free gadolinium ions have high toxicity, and thus they must be administered in chelated forms. Commonly used products are the gadolinium-based contrast agents. Just as satellites or global positioning systems (GPS) give traffic congestion information, the MRI contrast agents can give accurate information of vascular conditions such as vascular blockage and stenosis. In MRI, contrast agents improve the visibility of the structures such as smaller blood vessels within the body. For this purpose, imaging techniques such as magnetic resonance imaging (MRI) are widely used to identify the narrowing or blockage of blood vessels. As the disease often results in sudden death with few special prognostic symptoms, early diagnosis is very important. Heart attack and stroke are the first and second leading causes of death in developed countries, respectively. The new contrast agent offers a vast improvement over traditional gadolinium-based products
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |